… In contrast, shSOCS3 attenuated the effects of leptin (control = 1.15 ± 0.14 Hz; … Furthermore,
KLF4 protein is reduced in mice lacking leptin synthesis (ob/ob), suggesting that leptin is one …

… Mouse models that are deficient in leptin synthesis or … Leptin increases adult hippocampal
neurogenesis in the dentate … Attenuation of leptin action and regulation of obesity by protein …

… of LepRs in both rats and mice [2]. Furthermore, LepRs were identified in the mouse embryo
as early as embryonic day (E) 10.5 [3]. In ob/ob mice, deficiency of leptin leads to reduced …

… We here analyzed a mouse model of obesity (leptin-deficient mice) … hippocampal neurogenesis,
dendritic spine densities in hippocampal area CA1, and the behavior of the obese mice …

… receptor agonist, attenuated the metabolic syndromes and … Study on APPL2 Tg mice showed
that APPL2 could … The functions in regulating adult hippocampal neurogenesis indicate the …

… leptin-induced inhibition of corticosterone release could be a protective factor against PA. In
addition, leptin promotes hippocampal neurogenesis … enhancement of hippocampal synaptic …

… AMP-activated protein kinase (AMPK) regulates signalling pathways related to cell survival
and apoptosis and plays a role in increasing hippocampal neurogenesis [33]. It has been …

… In particular, our results demonstrate that leptin supplementation in pregnant rats
increased cell proliferation and nestin expression in the cerebral cortex of E15 and E17 fetal …

… defects in leptin signal transduction (30). However, other studies reported reduced plasma
leptin in MDD patients with a normal BMI (16, 17); this is consistent with rats or mice models of …

… Finally, we performed tests for anxiety using the same mice because the hippocampus has
been suggested to mediate untrained anxiety reactions [23]. The tests were not performed the …